Summary: No statistical heterogeneity of the effects by sex (P =0.2) was found; thus, men and women were analyzed together. Significant interactions were observed between the genotype at the PPARA locus and dietary Polyunsaturated Fats intake in the determination of serum TG (P=0.048) and apoC-III (P=0.01) concentrations. In both instances, those with the 162V allele had lower concentrations of TG and apoC-III with higher intake of Polyunsaturated Fats. In contrast, among homozygotes for the 162L allele, Polyunsaturated Fats intake did not decrease either TG or apoC-III concentrations.