Summary: Two months of caloric restriction with these diets significantly reduced BMI, weight, waist circumference, fat mass, systolic and diastolic blood pressures in obese patients. The study shows that carriers of the Thr54-containing protein have a different response than wild-type obese. Both diets decreased total cholesterol, triglyceride and insulin levels in the wild-type obese without statistical differences in carriers of the Thr54-containing protein. Glucose levels decreased with a low carbohydrate diet, too. Changes in serum leptin concentrations secondary to intervention were higher with low-fat diet than low-carbohydrate diet.

dbSNP: rs1799983

Disease: Metabolic syndrome


Summary: Following n-3 Polyunsaturated Fats supplementation, plasma TAG concentrations of minor allele carriers of rs1799983 were considerably more responsive to changes in plasma n-3 polyunsaturated Fats, than major allele homozygotes.

dbSNP: rs1800206

Disease: Metabolic syndrome/Cardiovascular disease