DystoGen is a comprehensive resource, which encompasses genetic variants from 124 dystonia-associated genes. The resource provides access to 30510 variants, which have been manually curated from published literature and open access public databases, and have been systematically annotated and classified according to ACMG & AMP (American College of Medical Genetics and the Association of Molecular Pathologists) guidelines. This database consists of clinically relevant informations which hold promise to aid clinicians, geneticists, and other researchers to understand and decipher the genetic component underlying the pathological condition. The study also provides scope for accurate diagnosis of rare dystonia-type disease and devising patient specific therapeutic regimens.