Architecture Architecture

almena is a comprehensive resource of genetic variants in Middle East and North Africa. The present version of the database provides information on over 26 million variants derived from integration of multiple whole genome and whole exome studies from the region. Apart from providing the allele frequencies for the genetic variants, this unique resource also provides relevant annotations for clinically relevant genetic variants.

The data set provided on this website encompasses 2115 unrelated individuals sequenced as part of various population-genetic as well as disease-specific studies. The datasets derived for the present version of the resource is listed here..

Rodriguez-Flores, J. L., Fakhro, K., Hackett, N. R., et al.
Exome Sequencing Identifies Potential Risk Variants for Mendelian Disorders at High Prevalence in Qatar. 
Human Mutation(2014)

Rodriguez-Flores, J. L., Fakhro, K., Agosto-Perez, F., et al.
Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations. 
Genome Research(2016)

Fakhro, K. A., Staudt, M. R., Ramstetter, M. D., et al.
The Qatar genome: a population-specific tool for precision medicine in the Middle East. 
Human genome variation(2016)

Ozcelik, T. and Onat, O. E.
Genomic landscape of the Greater Middle East. 
Nature Genetics(2016)

Iran genome : 

Please Note : Identity-by-descent(IBD) analysis of Qatar datasets revealed certain shared samples in the datasets. Qatar-1005 and Qatar-100 datasets shared 58 samples in common, while Qatar-100 and Qatar-108 have 31 samples in common. We have come across certain studies with small size of samples, which we have not included presently in the database

Cite this Resource:
Koshy R, Ranawat A, Scaria V.
almena - a comprehensive resource of human genetic variants integrating genomes and exomes from Arab, Middle Eastern and North African populations. J Hum Genet. 2017 Jun 22. doi: 10.1038/jhg.2017.67